Minor-groove width and accessibility in B-DNA drug and protein complexes
1992; Wiley; Volume: 298; Issue: 1 Linguagem: Inglês
10.1016/0014-5793(92)80030-k
ISSN1873-3468
Autores Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoA new definition is presented for minor‐groove width in double‐helical B‐DNA structures. This uses interstrand H4′…H5′ rather than P…P distances. It is shown by examination of various oligonucleotide crystal structures that these H4′…H5′ distances are a sensitive measure of minor‐groove drug and protein binding, since these hydrogen atoms are in direct non‐bonded contact with such bound ligands.
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