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Histologic evidence for impaired growth control in diphenylhydantoin gingival overgrowth in man

1978; Elsevier BV; Volume: 23; Issue: 5 Linguagem: Inglês

10.1016/0003-9969(78)90096-1

1879-1506

Thomas M. Hassell, Roy C. Page, Jan Lindhe,

Oral and Maxillofacial Pathology

Fibroblast density and collagen content in non-inflamed gingiva from patients with gingival overgrowth due to sodium 5,5-diphenylhydantoinate therapy were measured and compared to normal tissue. Direct counting of fibroblast nuclei as well as stereologic point-counting precedures were performed using stained microtome sections. In no case were fibroblasts more numerous or collagen fibres more ubiquitous in DPH-enlarged gingiva. The mature, fibrous-type DPH gingival lesion represents neither hypertrophy, hyperplasia nor fibrosis, but is an example of uncontrolled growth of a connective tissue of apparently normal cell and fibre composition.