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Kleisins: A Superfamily of Bacterial and Eukaryotic SMC Protein Partners

2003; Elsevier BV; Volume: 11; Issue: 3 Linguagem: Inglês

10.1016/s1097-2765(03)00108-4

1097-4164

Alexander Schleiffer, Susanne Kaitna, Sebastian Maurer‐Stroh, Michael Glotzer, Kim Nasmyth, Frank Eisenhaber,

Bacterial Genetics and Biotechnology

We describe a superfamily of eukaryotic and prokaryotic proteins (kleisins) that includes ScpA, Scc1, Rec8, and Barren. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family.