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Striatoids A–F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus

2015; American Chemical Society; Volume: 78; Issue: 4 Linguagem: Inglês

10.1021/np501030r

1520-6025

Rui Bai, Cheng‐Chen Zhang, Xia Yin, Jing Wei, Jin-Ming Gao,

Cancer Treatment and Pharmacology

Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A–F (1–6), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, 1H–1H–COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4′-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.