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Functional Cross-Talk of HIV-1 Tat with p53 through Its C-Terminal Domain

2001; Elsevier BV; Volume: 287; Issue: 2 Linguagem: Inglês

10.1006/bbrc.2001.5626

1090-2104

Yasuo Ariumi, Atsushi Kaida, Masakazu Hatanaka, Kunitada Shimotohno,

HIV Research and Treatment

Human immunodeficiency virus type 1 (HIV-1) Tat repressed the p53-dependent gene expression through its C-terminal domain of Tat (amino acid residues 73–86) independent of the involvement of NF-κB and coactivator CBP/p300. Although Tat did not directly bind to p53, this repression required the N-terminal domain of p53. In contrast, Tat and p53 cooperated in the activation of HIV-1 gene expression. Thus, the cross-talk between Tat and p53 may be linked with cellular transformation by HIV-1 infection or activation of HIV-1 replication.