Portal de Periódicos da CAPES

Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders

2005; Royal Society of Chemistry; Volume: 15; Issue: 35-36 Linguagem: Inglês

10.1039/b503680a

1364-5501

Hélène Roussière, Gilles Montavon, Samia Laı̈b, Pascal Janvier, Bruno Alonso, Franck Fayon, Marc Petit, Dominique Massiot, Jean‐Michel Bouler, Bruno Bujoli,

Chemical Synthesis and Characterization

The reaction of a bisphosphonate bone resorption inhibitor (Zoledronate) with calcium deficient hydroxyapatites (CDAs) was studied as a potential route to local drug delivery systems active against bone resorption disorders. A simple mathematical model of the Zoledronate–CDA interaction was designed that correctly described the adsorption of Zoledronate onto CDAs. The resulting Zoledronate-loaded materials were found to release the drug in different phosphate-containing media, with a satisfactory agreement between experimental data and the values predicted from the model.