Interaction between the pRb2/p130 C-terminal domain and the N-terminal portion of cyclin D3
1999; Wiley; Volume: 75; Issue: 4 Linguagem: Inglês
10.1002/(sici)1097-4644(19991215)75
ISSN1097-4644
AutoresFrancesco Bonetto, Maurizio Fanciulli, Tullio Battista, Antonio De Luca, Patrizia Russo, Tiziana Bruno, Roberta De Angelis, Monica Di Padova, Antonio Giordano, Armando Felsani, Marco G. Paggi,
Tópico(s)Genomics and Chromatin Dynamics
ResumoJournal of Cellular BiochemistryVolume 75, Issue 4 p. 698-709 Research Article Interaction between the pRb2/p130 C-terminal domain and the N-terminal portion of cyclin D3 Francesco Bonetto, Francesco Bonetto Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorMaurizio Fanciulli, Maurizio Fanciulli Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorTullio Battista, Tullio Battista Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorAntonio De Luca, Antonio De Luca Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, Italy Departments of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107Search for more papers by this authorPatrizia Russo, Patrizia Russo Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorTiziana Bruno, Tiziana Bruno Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorRoberta De Angelis, Roberta De Angelis Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorMonica Di Padova, Monica Di Padova Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorAntonio Giordano, Antonio Giordano Departments of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107Search for more papers by this authorArmando Felsani, Armando Felsani Istituto Tecnologie Biomediche CNR, 00137 Rome, ItalySearch for more papers by this authorMarco G. Paggi, Corresponding Author Marco G. Paggi [email protected] Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalyLaboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, Via delle Messi d'Oro, 156, 00158 Rome, Italy.Search for more papers by this author Francesco Bonetto, Francesco Bonetto Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorMaurizio Fanciulli, Maurizio Fanciulli Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorTullio Battista, Tullio Battista Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorAntonio De Luca, Antonio De Luca Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, Italy Departments of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107Search for more papers by this authorPatrizia Russo, Patrizia Russo Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorTiziana Bruno, Tiziana Bruno Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorRoberta De Angelis, Roberta De Angelis Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorMonica Di Padova, Monica Di Padova Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalySearch for more papers by this authorAntonio Giordano, Antonio Giordano Departments of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107Search for more papers by this authorArmando Felsani, Armando Felsani Istituto Tecnologie Biomediche CNR, 00137 Rome, ItalySearch for more papers by this authorMarco G. Paggi, Corresponding Author Marco G. Paggi [email protected] Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, 00158 Rome, ItalyLaboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, Via delle Messi d'Oro, 156, 00158 Rome, Italy.Search for more papers by this author First published: 09 November 1999 https://doi.org/10.1002/(SICI)1097-4644(19991215)75:4 3.0.CO;2-7Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract An association between cyclin D3 and the C-terminal domain of pRb2/p130 was demonstrated using the yeast two-hybrid system. Further analysis restricted the epitope responsible for the binding within the 74 N-terminal amino acids of cyclin D3, independent of the LXCXE amino acid motif present in the D-type cyclin N-terminal region. In a coprecipitation assay in T98G cells, a human glioblastoma cell line, the C-terminal domain of pRb2/p130 was able to interact solely with cyclin D3, while the corresponding portion of pRb interacted with either cyclin D3 or cyclin D1. In T98G cells, endogenous cyclin D3-associated kinase activity showed a clear predisposition to phosphorylate preferentially the C-terminal domain of pRb2/p130, rather than that of pRb. 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