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Eph/ephrin signalling during development

2012; The Company of Biologists; Volume: 139; Issue: 22 Linguagem: Inglês

10.1242/dev.074997

1477-9129

Rüdiger Klein,

Zebrafish Biomedical Research Applications

Eph receptors and their membrane-tethered ligands have important functions in development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles.