Sensitivity of Actinomyces Israeli to Antibiotics
1952; BMJ; Volume: 1; Issue: 4771 Linguagem: Inglês
10.1136/bmj.1.4771.1263
ISSN0959-8138
Autores Tópico(s)Cholangiocarcinoma and Gallbladder Cancer Studies
ResumoAlthough sulphonamides have some' effect in actino- mycosis, penicillin has much more, and is now the stan- dard treatment for this disease.There are nevertheless three reasons for inquiring into the possible usefulness of later antibiotics: they may conceivably be even more effective, a given patient's strain of Actinomyces israeli may be or become abnormally resistant to penicillin, or the patient may be intolerfit of this drug.There are records of the treatment of small numbers of cases of actinomycosis with antibiotics-other than penicillin.Streptomycin was used successfully by Costigan (1947) in one atypical and not fully confirmed case, by Pemberton and Hunter (1949), who gave the drug by the mouth to a patient with a lesion in the rectum, by Torrens and Wood (1949), who treated three authenticated cases by a prolonged course of injections, and by Lambert (1951).Some of these patients had previously been given penicillin with no or only tem- porary benefit Pulaski and Seeley (1948) mention a case in which tlae organism became resistant to the drug and the disease progressed: that a high degree of such resistance can develop in vitro has been shown by Boand and Novak (1949).All clinical reports on the response of the disease to aureomycin are enthusiastic: Wright and Lowen (1950) cured one case, McVay, Guthrie, and Sprunt (1951) three, Grant (1951) one, and Kelly (1951) one, which had previously not responded at all to streptomycin or penicillin, and only tem- porarily to chloramphenicol.Chloramphenicol was employed successfully together with penicillin and sulphadiazine in one patient by Littman, Phillips, and Fusillo (1950).There are also single case reports of
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