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Antiviral Phenolic Compounds from Arundina gramnifolia

2013; American Chemical Society; Volume: 76; Issue: 2 Linguagem: Inglês

10.1021/np300727f

1520-6025

Qiu-Fen Hu, Bin Zhou, Jian Huang, Xue-Mei Gao, Li-Dan Shu, Guang‐Yu Yang, Chun-Tao Che,

Bioactive natural compounds

Five new phenolic compounds, gramniphenols C–G (1–5), and eight known compounds (6–13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 μM, respectively. Compounds 1–10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.