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Relative Potency of the Atropine-Like Effects of A New parasympatholytic Drug, Scopolamine-N-(Cyclopropy 1 Methyl) Bromide and Those of Hyoscine-N-Butyl Bromide

1977; Taylor & Francis; Volume: 5; Issue: 4 Linguagem: Inglês

10.1185/03007997709110189

1473-4877

R. Litta Modignani, M. Mazzolari, E. Barantani, Daniele Bertoli, C Vibelli,

Epilepsy research and treatment

SummaryA Double-Blind Crossover Trial With A 4-Point Bioassay Was Carried Out In 8 Convalescent In-Patients To Study The Relative Potency Of Scopolamine-N-(Cyclopropyl Methyl) Bromide (Da 3177), A New parasympatholytic Drug, Administered At Doses Of 2.5 mg And 5 mg I.V., And Hyoscine-N-Butyl Bromide, Administered At Doses Of 10 mg And 20 mg I.V., In Producing Atropine-Like Effects. The Results Showed That The Effects On Heart Rate And Near Point Of Accommodation Were Slightly Less With Da 3177, While Its Effects On Salivary Secretion Were A Little Greater Than Those Of Hyoscine-N-Butyl Bromide. It Is Suggested That Study Of The Pharmacodynamic Effects Of parasympatholytic Drugs Is A Relatively Simple Way Of Predicting Which Doses Should Be Effective Spasmolytically.