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Metabolic Dysfunction Under Reduced Estrogen Levels

2012; Lippincott Williams & Wilkins; Volume: 40; Issue: 4 Linguagem: Inglês

10.1097/jes.0b013e31825eab9f

1538-3008

Espen E. Spangenburg, Lindsay M. Wohlers, Ana P. Valencia,

Adipokines, Inflammation, and Metabolic Diseases

Loss of estrogen function leads to the development of metabolic dysfunction that spans numerous tissues. In this review, we explore the concept that estrogens are critical for defining metabolic function in adipose and hepatic tissues and also the possibility that exercise training should be considered a substitute for estrogen replacement therapy in women with impairments in estrogen levels.