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Escape from the sodium-retaining effects of mineralocorticoids: Role of ANF and intrarenal hormone systems

1989; Elsevier BV; Volume: 35; Issue: 3 Linguagem: Inglês

10.1038/ki.1989.51

1523-1755

Michael J. Gonzalez-Campoy, C. Jiménez Romero, Franklyn G. Knox,

Hormonal Regulation and Hypertension

Chronic exposure to either endogenous or exogenous mineralocorticoid excess results in a syndrome characterized by hypokalemia, metabolic alkalosis, polydipsia, polyuria, and mild arterial pressure elevation. Contrary to what might be expected from the mechanism of action of these hormones, there is only a transient period of positive sodium balance (Fig. 1). The expansion of the extracellular fluid volume is maintained as evidenced by an increase in body weight even after sodium balance is restored. However, this elevation of the extracellular fluid volume is not striking, and congestive heart failure is not part of the syndrome [1].