Liposome and protein based stealth nanoparticles
2013; Royal Society of Chemistry; Volume: 166; Linguagem: Inglês
10.1039/c3fd00057e
ISSN1364-5498
AutoresEugénia Nogueira, Ana Loureiro, Patrícia Nogueira, Jaime Freitas, Catarina R. Almeida, Johan Härmark, Hans Hebert, Alexandra Moreira, Alexandre M. Carmo, Ana Preto, Andreia C. Gomes, Artur Cavaco‐Paulo,
Tópico(s)Characterization and Applications of Magnetic Nanoparticles
ResumoLiposomes and protein based nanoparticles were tuned with different polymers and glycolipids to improve stealth and thus decrease their clearance by macrophages. Liposomes were coated with polyethylene glycol (PEG) and brain-tissue-derived monosialoganglioside (GM1). Bovine serum albumin (BSA) nanoparticles were produced incorporating a PEGylated surfactant (PEG-surfactant). All obtained nanoparticles were monodisperse, with sizes ranging from 80 to 120 nm, with a zeta-potential close to zero. The presented stealth strategies lead to a decrease of internalization levels by macrophages. These surface modified nanoparticles could be used for production of new drug delivery nanosystems for systemic administration (e.g. intravenous application).
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