Chloroperoxidase and hydrogen peroxide: An efficient system for enzymatic enantioselective sulfoxidations.
1992; Elsevier BV; Volume: 3; Issue: 1 Linguagem: Inglês
10.1016/s0957-4166(00)82316-2
ISSN1362-511X
AutoresStefano Colonna, Nicoletta Gaggero, Luigi Casella, Giacomo Carrea, Piero Pasta,
Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoHigh enantioselectivities were obtained in chloroperoxidase catalyzed oxidation of organic sulfides ( 99% ee in the case of methyl 2-pyridyl sulfide) with H2O2 in aqueous buffer solution, pH 5, at 25°C. The kinetic parameters in the oxidation of a series of sulfides both with H2O2 and tert-butyl hydroperoxide were determined and the data are consistent with enzymatic oxidation involving presumably a ternary complex, in all cases the reaction afforded the (R) sulfoxide as predominant or exclusive enantiomer.
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