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Labeled bile acids I: Synthesis of 18 O‐methyl hydroxy‐5β‐cholan‐24‐oates

1984; Wiley; Volume: 21; Issue: 1 Linguagem: Inglês

10.1002/jlcr.2580210106

1099-1344

Warren G. Anderson, Chang Yon Byon, Charles R. Eck, Marcel Gut,

Metabolism and Genetic Disorders

Abstract The incorporation of 18 O into the 3‐hydroxyl of bile acids has been accomplished by hydrolysis of the acetal corresponding to the 3‐oxo bile acid with H 2 O, followed by hydride reduction of the ketone to the labeled hydroxyl function.