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Reagent -Controlled Stereoselective Iodolactonizations

2001; American Chemical Society; Volume: 4; Issue: 2 Linguagem: Inglês

10.1021/ol0171113

1523-7060

Juergen Haas, Sandrine Piguel, Thomas Wirth,

Catalytic C–H Functionalization Methods

[reaction: see text] Iodocyclizations are important transformations and among stereocontrolled iodocyclizations mostly substrate-controlled versions using a chiral auxiliary have been successfully investigated. This work reports on stereoselective reagent-controlled iodolactonizations applying a new method using a combination of ICl and a primary amine leading to the highest selectivities known so far.