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BIBTEX RIS

An improved synthesis of N-acetoxy-N-acetyl-2-aminofluorene-9-14C using an extractive acylation technique

1978; Wiley; Volume: 15; Issue: S1 Linguagem: Inglês

10.1002/jlcr.2580150109

ISSN

1099-1344

Autores

M. R. Thissen, W. P. Duncan,

Tópico(s)

Fluorine in Organic Chemistry

Resumo

A rapid, high yield (90–100%) method for the preparation of N-acetoxy-N-acetyl-2-aminofluorene-9-14C (N-AcO-AAF-9-14C) from N-hydroxy-N-acetyl-2-aminofluorene-9-14C (N-OH-AAF-9-14C) is described. The procedure consists of the in situ formation of a quaternary ammonium salt of N-OH-AAF-9-14C in a two-phase system and subsequent acetylation of this salt with acetic anhydride. The specific activity of the product was 40.6 mCi/mmole.

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