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Multiple sclerosis: Clinical characteristics and disability progression in Moroccan children

2014; Elsevier BV; Volume: 346; Issue: 1-2 Linguagem: Inglês

10.1016/j.jns.2014.08.008

1878-5883

E. Aït Ben Haddou, Mounia Alhyan, Jehanne Aasfara, W. Regragui, Azeddine Ibrahimi, Rachid Razıne, Rédouane Abouqal, Ali Benomar, Mohamed Yahyaoui,

Multiple Sclerosis Research Studies

Abstract Background 5% of multiple sclerosis have their onset in childhood. Objectives We aim to show the clinical features and follow-up of Moroccan pediatric MS patients. Methods 25 pediatric MS records were analyzed between 2005 and 2013 at the Neurology B department of Rabat Ibn sina University Hospital and Medical School Group of Neurogenetic Disorder of Rabat Mohammed V University Souissi. Results The median duration of follow up was 4years [1.56]. The median age at disease onset was 14years. Clinical symptoms were described. At the last evaluation, the median EDSS score was 3.0 [0–7.5]. The median time between disease onset and diagnosis was 2years [1–9] and the median time from MS onset to second neurological episode was 1year [0.9–3] with an average of 2 relapses in the first 2years. The median time to reach EDSS 3.0 was 4.5years [2–17] and the median time to go from EDSS 3.0 to 6.0 was 4years [2.5–6]. The majority of cases at the last follow-up were; relapsing–remitting (17 patients: 68%), although 8 patients (32%) developed secondary progressive MS after median disease duration of 5years [4–19]. None of the patients had a primary progressive MS. Conclusion Time EDSS 3.0 and to secondary progression was shorter in our cohort than previously reported in other series.