Low-dose aspirin and subsequent peripheral arterial surgery in the Physicians' Health Study
1992; Elsevier BV; Volume: 340; Issue: 8812 Linguagem: Inglês
10.1016/0140-6736(92)93216-a
ISSN1474-547X
AutoresSamuel Z. Goldhaber, JoAnn E. Manson, Meir J. Stampfer, F Lamotte, Bernard Rosner, Julie E. Buring, C H Hennekens,
Tópico(s)Antiplatelet Therapy and Cardiovascular Diseases
ResumoIn the US Physicians' Health Study the early termination of the aspirin arm has provided the opportunity to test the hypothesis that low-dose aspirin (325 mg on alternate days) might affect the subsequent occurrence of peripheral arterial surgery. In the study, a randomised double-blind placebo-controlled trial among 22 071 healthy US male physicians aged 40-84, there were, during an average of 60·2 months of treatment and follow-up, 56 participants who underwent peripheral arterial surgery (20 aspirin, 36 placebo). The relative risk of peripheral artery surgery in the aspirin group was 0·54 (95% confidence intervals 0·30-0·95; p = 0·03). These data indicate that chronic administration of low-dose aspirin to apparently healthy men reduced the need for peripheral arterial surgery.
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