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The Relationship of the Juxtaglomerular Apparatus to Sodium Retention in Experimental Nephrosis

1962; American College of Physicians; Volume: 57; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-57-3-382

1539-3704

Louis Tobian,

Ion Transport and Channel Regulation

Article1 September 1962The Relationship of the Juxtaglomerular Apparatus to Sodium Retention in Experimental NephrosisLOUIS TOBIAN, M.D., SANDRA PERRY, B.S., JOHN MORK, B.A.LOUIS TOBIAN, M.D., SANDRA PERRY, B.S., JOHN MORK, B.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-382 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhenever rats, dogs, or cats are given a sodium deficient diet for a month or 2, the granules in the cytoplasm of juxtaglomerular cells become much more abundant, and the cells themselves often become hyperplastic (1, 2). The opposite effect is seen in rats when a diet containing 7.4 per cent sodium chloride is used. When rats eat these large quantities of salt, the granularity of the juxtaglomerular cells diminishes (3). The actual sodium concentration in the extracellular fluid is scarcely changed by these variations in sodium intake. Hence, attention is focused on changes in extracellular fluid volume or blood...References1. HARTROFTNEWMARKPITCOCK PMLNJA: Relationship of renal juxtaglomerular cells to sodium intake, adrenal cortex and hypertension, in Hypertension, ed. by Moyer, J. H., W. B. Saunders Company, Philadelphia, 1959, p. 24. Google Scholar2. TOBIANTHOMPSONTWEDTJANECEK LJRJ: The granulation of juxtaglomerular cells in renal hypertension, desoxycorticosterone and post-desoxycorticosterone hypertension, adrenal regeneration hypertension, and adrenal insufficiency. J. Clin. Invest. 37: 660, 1958. CrossrefMedlineGoogle Scholar3. TOBIAN L: Physiology of the juxtaglomerular cells. Ann. Intern. Med. 52: 395, 1960. LinkGoogle Scholar4. FRIEDMANFREED MSC: Microphonic manometer for indirect determination of systolic blood pressure in the rat. Proc. Soc. Exp. Biol. 70: 670, 1949. CrossrefMedlineGoogle Scholar5. HARTROFTHARTROFT PMWS: Studies on renal juxtaglomerular cells. I. 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CrossrefMedlineGoogle Scholar16. TOBIANCOFFEEFERREIRAMEULI LKDJ: The effect of renal perfusion pressure on the active transport of sodium out of distal tubular urine as studied with the "stop-flow" technique. J. Clin. Invest. 41: 1404, 1962. Google Scholar17. DAVISHOWELLSOUTHWORTH JODSJL: Mechanisms of fluid and electrolyte retention in experimental preparations in dogs. III. Effect of adrenalectomy and subsequent desoxycorticosterone acetate administration on ascites formation. Circulat. Res. 1: 260, 1953. CrossrefMedlineGoogle Scholar18. BRAUN-MENENDEZMARTINEZ EC: Aumento del volumen sanguineo y del liquido extracelular en ratas diabeticas e hipertensas. Rev. Soc. Argent. Biol. 25: 168, 1949. Google Scholar19. LEDINGHAM JM: Distribution of water, sodium, and potassium in heart and skeletal muscle in experimental renal hypertension in rats. Clin. Sci. 12: 337, 1953. MedlineGoogle Scholar20. SAHLI H: Herzmittel und Vasomotorenmittel, zweites referat. Verh. Deutsch. Cong. Inn. Med. 19: 45, 1901. Google Scholar21. FRIIS T: Studies on Sahli's high pressure stasis. Acta Med. Scand. 132: 181, 1948. CrossrefGoogle Scholar22. LANGFORD HO: Discussion at the annual meeting of the Central Society for Clinical Research, Chicago, November 3, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Internal Medicine, University of Minnesota Hospital and School of Medicine, Minneapolis, Minnesota.Presented at the annual meeting of the Central Society for Clinical Research, November 3, 1961.Supported by a grant from the American Heart Association, by grant H-2008, National Heart Institute, United States Public Health Service, and by a grant from the Cargill Foundation.Requests for reprints should be addressed to Louis Tobian, M.D., Department of Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota. 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D. ITSKOVITZ, M.D., E. A. HILDRETH, M.D., F.A.C.P., A. M. SELLERS, M.D., F.A.C.P., W. S. BLAKEMORE, M.D., F.A.C.S.Juxtaglomerular Cells 1 September 1962Volume 57, Issue 3Page: 382-388KeywordsAscitesAttentionCellsDietHeartHospital medicineMedical servicesSaltsSodiumSodium chloride Issue Published: 1 September 1962 PDF DownloadLoading ...