Portal de Periódicos da CAPES

Beyond binding: using phage display to select for structure, folding and enzymatic activity in proteins

1999; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês

10.1016/s0959-440x(99)80073-6

1879-033X

Patrik Forrer, Steffen Jung, Andreas Plückthun,

Chemical Synthesis and Analysis

Phage display of a wide range of polypeptides has been increasingly used to identify novel molecules with useful binding properties for research, medical and industrial applications. Recent developments include methods for the selection of stabilized variants of a protein, the selection of regulatable enzymes and promising strategies for the selection and evolution of protein catalysts.