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Identification of Deoxymiroestrol as the Actual Rejuvenating Principle of “Kwao Keur”, Pueraria m irifica . The Known Miroestrol May Be an Artifact

2000; American Chemical Society; Volume: 63; Issue: 2 Linguagem: Inglês

10.1021/np990547v

1520-6025

Sunee Chansakaow, Tsutomu Ishikawa, Hiroko Seki, Keiko Sekine, Mineaki Okada, Chaiyo Chaichantipyuth,

Cholesterol and Lipid Metabolism

Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.