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Origins of DNA replication that function in eukaryotic cells

1993; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/0955-0674(93)90008-e

1879-0410

Melvin L. DePamphilis,

Bacterial Genetics and Biotechnology

This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and complex genomes, but origins in complex genomes may include nuclear structure as well as DNA sequence.