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TREATMENT OF PEYRONIE'S DISEASE WITH INTRALESIONAL VERAPAMIL INJECTION

1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(01)64224-1

1527-3792

Laurence A. Levine,

Urinary Bladder and Prostate Research

No AccessJournal of UrologyClinical Urology: Original Articles1 Oct 1997TREATMENT OF PEYRONIE'S DISEASE WITH INTRALESIONAL VERAPAMIL INJECTION Laurence A. Levine Laurence A. LevineLaurence A. Levine View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64224-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In a previous study, 83% of 14 patients noted that their symptoms of Peyronie's disease had arrested or improved after intralesional injection of verapamil. This nonrandomized, prospective study further investigates the use of verapamil in a larger, thoroughly characterized patient population. Materials and Methods: Forty-six men began treatment; 38 completed the study. Using a multiple puncture technique, 10 mg. of verapamil diluted to 10 cc were distributed throughout the plaque every 2 weeks for a total of 12 injections. Response to treatment was evaluated through subjective and objective measurements of pain, plaque size, deformity, duration of disease and sexual function, and with the Kelami classification system based on plaque size and curvature. Results: Pain resolved in 97% of the patients who presented with pain after a mean of 2.5 injections. After therapy, 76% reported a subjective decrease in curvature, 9.5% noted an increase and 14.5% remained unchanged. Of the treated patients 72% reported an improvement in the ability to engage in coitus. Objective measurements demonstrated that curvature was decreased in 54% of the patients, increased in 11% and remained unchanged in 34%. There were no substantial differences in response to treatment based on duration of disease or within the 3 Kelami classification groups. Other than transient post-injection ecchymosis, there were no significant acute or chronic side effects. Conclusions: Verapamil injection therapy resulted in a reduction of pain in 97% of the patients, an improvement in sexual function in 72%, a reduction of deformity in 86%, an improvement in distal rigidity in 93% and an objective reduction of curvature in 54%. Further studies are required to determine the effectiveness of this nontoxic, inexpensive, nonsurgical approach to Peyronie's disease. References 1 : Intralesional verapamil injection for the treatment of Peyronie's disease.. J. Urol.1994; 151: 1522. Abstract, Google Scholar 2 : Nov metod za Ischenie na bolestta na Peironi.. Khirurgiia1989; 42: 30. Google Scholar 3 : Possibilita di impiego del litotritore piezoelottrico nel trattamento delle fibrosi cavernose gravi.. Arch. Ital. Urol. Nefrol. Androl.1989; 61: 417. Google Scholar 4 : The ultrasonic treatment of Peyronie's disease.. J. Urol.1971; 106: 83. Google Scholar 5 : New concept in treatment of Peyronie's disease.. South. Med. J.1948; 41: 173. 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Google Scholar From the Department of Urology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySIROKY M and AZADZOI K (2018) Vasculogenic Erectile Dysfunction: Newer Therapeutic StrategiesJournal of Urology, VOL. 170, NO. 2S, (S24-S30), Online publication date: 1-Aug-2003.GHOLAMI S, GONZALEZ-CADAVID N, LIN C, RAJFER J and LUE T (2018) Peyronie's Disease: A ReviewJournal of Urology, VOL. 169, NO. 4, (1234-1241), Online publication date: 1-Apr-2003.MARTIN D, BADWAN K, PARKER M and MULHALL J (2018) Transdermal Application of Verapamil Gel to the Penile Shaft Fails to Infiltrate the Tunica AlbugineaJournal of Urology, VOL. 168, NO. 6, (2483-2485), Online publication date: 1-Dec-2002.Levine L, Goldman K and Greenfield J (2018) Experience With Intraplaque Injection of Verapamil for Peyronie's DiseaseJournal of Urology, VOL. 168, NO. 2, (621-626), Online publication date: 1-Aug-2002.CHUN J, McGREGOR A, KRISHNAN R and CARSON C (2018) A COMPARISON OF DERMAL AND CADAVERIC PERICARDIAL GRAFTS IN THE MODIFIED HORTON-DEVINE PROCEDURE FOR PEYRONIE'S DISEASEJournal of Urology, VOL. 166, NO. 1, (185-188), Online publication date: 1-Jul-2001.EL-SAKKA A, BAKIRCIOGLU M, BHATNAGAR R, YEN T, DAHIYA R and LUE T (2018) THE EFFECTS OF COLCHICINE ON A PEYRONIE'S-LIKE CONDITION IN AN ANIMAL MODELJournal of Urology, VOL. 161, NO. 6, (1980-1983), Online publication date: 1-Jun-1999.Wegner H, Andresen R, Knispel H and Miller K (2018) Local Interferon-Alpha2b is Not an Effective Treatment in Early-Stage Peyronie's DiseaseJournal of Urology, VOL. 159, NO. 5, (1777-1778), Online publication date: 1-May-1998. Volume 158Issue 4October 1997Page: 1395-1399 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Laurence A. Levine More articles by this author Expand All Advertisement PDF downloadLoading ...