Spectrophotometric determination of tranexamic acid with chloranil
1984; Elsevier BV; Volume: 31; Issue: 1 Linguagem: Inglês
10.1016/0039-9140(84)80015-6
ISSN1873-3573
AutoresAbdel-Aziz M. Wahbi, Essam A. Lotfi, Hassan Y. Aboul‐Enein,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoTranexamic acid is reacted with aqueous alcoholic chloranil, buffered at pH 9, to give a complex with maximum absorption at 346 nm and with an apparent molar absorptivity of 15.7 x 10(3) l.mole(-1).cm(-1). A(max) is linearly related to concentration over the range 2-10 mug ml . When applied to tablets labelled as containing 500 mg each, the mean found was 496 +/- 4 mg. The results were comparable with those of the traditional formol titration method for amino-acids.
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