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Tc-99m Sestamibi Thyroid Imaging in Patients on Chronic Amiodarone Treatment

2010; Lippincott Williams & Wilkins; Volume: 35; Issue: 4 Linguagem: Inglês

10.1097/rlu.0b013e3181d18e8e

1536-0229

Gláucia Celeste Rossatto Oki, Denise Engelbrecht Zantut‐Wittmann, Allan O. Santos, Maria Helena Guariento, Marcos Antônio Tambascia, Eros Antônio de Almeida, Bárbara Juarez Amorim, Mariana Lima, Elba Etchebehere, Edwaldo E. Camargo, Celso Darío Ramos,

Ion channel regulation and function

Purpose of the Report: To compare thyroid imaging using Tc-99m sestamibi with the standard Tc-99m pertechnetate scintigraphy in patients on chronic use of amiodarone. Materials and Methods: A total of 23 patients on oral amiodarone for at least 4 months had thyroid scintigraphy and uptake measurement using Tc-99m pertechnetate and Tc-99m sestamibi. Thyroid function was evaluated by measuring serum concentrations of thyrotropin, free thyroxine, and free triiodothyronine, and antithyroglobulin and antithyroperoxidase antibodies. Results: Ten of the 23 patients were euthyroid, 9 hypothyroid, and 4 hyperthyroid, with normal, increased, and decreased serum thyrotropin, respectively. All euthyroid patients had markedly decreased thyroid Tc-99m pertechnetate uptake and normal or slightly increased Tc-99m sestamibi uptake, except for one patient who had increased uptake of both radiotracers. One of the 4 hyperthyroid patients had Graves' disease and markedly increased thyroid uptake of both tracers. The other 3 hyperthyroid patients had normal or decreased Tc-99m pertechnetate uptake and increased Tc-99m sestamibi uptake. Differently than expected, all 9 hypothyroid patients had normal or increased uptake of both radiopharmaceuticals. Conclusions: This study suggests that Tc-99m sestamibi may be an alternative tracer for thyroid scintigraphy and uptake measurement of patients on chronic use of amiodarone. Tc-99m sestamibi seems to be better than Tc-99m pertechnetate for the scintigraphic evaluation of the thyroid of euthyroid and hyperthyroid patients.