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Nature of the nervous control of pars intermedia function in amphibians: Rate of functional recovery after denervation

1963; Elsevier BV; Volume: 3; Issue: 5 Linguagem: Inglês

10.1016/0016-6480(63)90078-9

1095-6840

Christian Jørgensen, Lis Olesen Larsen,

Nerve injury and regeneration

The rate and extent of recovery of the control of pars intermedia function have been followed in Xenopus laevis and Bufo bufo after denervation of the neurointer-mediate lobe of the hypophysis, and in metamorphosed Ambystoma mexicanum after extirpation and transplantation of the whole hypophysis onto the infundibulum. All three species behaved in a similar way. Control of intermedin release could not be demonstrated for at least some weeks after the operation, but in most cases a weak control was re-established after one to several months and up to 1 year. In one Xenopus, control had not reappeared even after a period of almost 2 year. After the reappearance of an incomplete control, further progress was slow and normal conditions were often never reached. The results are discussed, and it is concluded that the pattern of events during the re-establishment of control of pars intermedia function after sectioning of its nerve supply is consistent with the theory that this control is mediated by ordinary nerves and not by neurosecretory nerves.