Adenosine A 1 receptor and ligand molecular modeling
1993; Wiley; Volume: 28; Issue: 3 Linguagem: Inglês
10.1002/ddr.430280309
ISSN1098-2299
AutoresMark W. Dudley, Norton P. Peet, David A. Demeter, Herschel J. R. Weintraub, Adriaan P. IJzerman, Gunnar Nordvall, Philip J. M. van Galen, Kenneth A. Jacobson,
Tópico(s)Molecular Sensors and Ion Detection
ResumoAbstract This symposium provided a forum for presentations by the relevant groups on ligand design and ligand binding on the adenosine A 1 receptor. Agreement appears to exist that the “N 6 C 8 ” model of ligand binding to the receptor is the preferred mode. A consensus has not yet been reached on the actual placement of the ligand in the receptor and the exact amino acids which interact in its binding. Two viable models exist at present. Both can be tested with selective site‐directed mutagenic studies on the A 1 receptor as well as with additional designed ligands. © 1993 Wiley‐Liss, Inc.
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