Monoamine oxidase and catechol-o-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome
1980; Elsevier BV; Volume: 2; Issue: 2 Linguagem: Inglês
10.1016/0165-1781(80)90076-1
ISSN1872-7123
AutoresEarl L. Giller, J. Gerald Young, Xandra O. Breakefield, C. M. Carbonari, Muriel Braverman, Donald J. Cohen,
Tópico(s)Child Nutrition and Feeding Issues
ResumoMonoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) activities were measured in cells from children with autism (n=5) and the Gilles de la Tourette syndrome (n=5). Monoamine oxidase activities in cultured skin fibroblasts (type A) and platelets (type B) from the same individual were not correlated. COMT activities in fibroblasts and red blood cells showed a negative but not significant correlation (r=-0.42). Fibroblast MAO and COMT activities from patients were similar to values from controls matched for age, race, and sex. Increasing clinical severity of illness in both disorders, however, correlated significantly with higher fibroblast MAO activity. Cultured fibroblasts provide a means of measuring enzyme activities independently of the individual's current physiological and psychological state.
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