The crystal structures of DNA Holliday junctions
2001; Elsevier BV; Volume: 11; Issue: 3 Linguagem: Inglês
10.1016/s0959-440x(00)00219-0
ISSN1879-033X
AutoresP Shing Ho, Brandt F. Eichman,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoNearly 40 years ago, Holliday proposed a four-stranded complex or junction as the central intermediate in the general mechanism of genetic recombination. During the past two years, six single-crystal structures of such DNA junctions have been determined by three different research groups. These structures all essentially adopt the antiparallel stacked-X conformation, but can be classified into three distinct categories: RNA–DNA junctions; ACC trinucleotide junctions; and drug-induced junctions. Together, these structures provide insight into how local and distant interactions help to define the detailed and general physical features of Holliday junctions at the atomic level.
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