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Characterization of physiological agonist selectivity of human fat cell α2-adrenoceptors: Adrenaline is the major stimulant of the α2-adrenoceptors

1982; Elsevier BV; Volume: 82; Issue: 1-2 Linguagem: Inglês

10.1016/0014-2999(82)90562-3

1879-0712

Max Lafontan, M Berlan,

Receptor Mechanisms and Signaling

The study was based on biological assays (stimulation or inhibition of lipolysis) done with isolated human fat cells in association with simultaneous radioligand ([3H]yohimbine) binding studies on fat cell membranes. It was demonstrated that (−)-adrenaline, as opposed to (−)-noradrenaline, is the major stimulant of human fat cell α2-adrenoceptors. In adipose tissue the α2-adrenoceptors are located postsynaptically and even extrasynaptically.