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pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid

2001; Wiley; Volume: 172; Issue: 1 Linguagem: Inglês

10.1002/1521-3900(200107)172

1521-3900

Niren Murthy, Isiah Chang, Patrick S. Stayton, Allan S. Hoffman,

Electrostatics and Colloid Interactions

Macromolecular SymposiaVolume 172, Issue 1 p. 49-56 Article pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid Niren Murthy, Niren Murthy Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorIsiah Chang, Isiah Chang Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorPat Stayton, Pat Stayton Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorAllan Hoffman, Allan Hoffman Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this author Niren Murthy, Niren Murthy Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorIsiah Chang, Isiah Chang Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorPat Stayton, Pat Stayton Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this authorAllan Hoffman, Allan Hoffman Department of Bioengineering, Box #352255, University of Washington, Seattle, WA 98195, USASearch for more papers by this author First published: 30 August 2001 https://doi.org/10.1002/1521-3900(200107)172:1 3.0.CO;2-YCitations: 46AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract We have been designing and synthesizing synthetic polymers that mimic viral fusogenic peptides, which contain peptide residues having alkyl groups and carboxyl groups. We have synthesized two different types of such polymers, and their abilities to hemolyse red blood cells at pH 7.4 and 5.5 are compared here. The polymers are poly(2-alkylacrylic acid)s such as poly(2-propylacrylic acid), and random copolymers of poly(alkyl acrylate-co-acrylic acid) where the alkyl group is propyl or butyl. We have found that the poly(2-alkylacrylic acid)s such as poly(2-propylacrylic acid) are significantly more hemolytic at acidic pH than the random copolymers of equivalent propyl and carboxyl contents. Citing Literature Volume172, Issue1July 2001Pages 49-56 RelatedInformation