Sequential treatment of recurrent mesenteric desmoid tumor
1996; Wiley; Volume: 77; Issue: 6 Linguagem: Inglês
10.1002/(sici)1097-0142(19960315)77
ISSN1097-0142
AutoresThomas Bauernhofer, Herbert Stöger, Marianne Schmid, M.G. Smola, Barbara Gürtl-Lackner, Gerald Höfler, G. Ranner, Emil C. Reisinger, Hellmut Samonigg,
Tópico(s)Tumors and Oncological Cases
ResumoThe optimal management of inoperable desmoid tumors is still unclear. We report a 26 year-old female patient with familial adenomatous polyposis suffering from a recurrent inoperable intraabdominal desmoid tumor and its sequential treatment.Treatment strategies included low-dose tamoxifen (30 mg orally per day), high-dose tamoxifen (90 mg orally per day), and a subsequent combination of goserelin acetate (3.6 mg subcutaneously once every four weeks) plus low-dose tamoxifen, medroxyprogesterone acetate (1000 mg orally per day) and interferon gamma (3 Mio IU subcutaneously 3 times a week).The combination of goserelin acetate and low-dose tamoxifen resulted in a decrease in tumour size and a complete relief of symptoms for 17 months. Thereafter the tumor progressed and again growth was stopped with interferon gamma therapy for another 6 months. All other treatment modalities had no effect.This study demonstrates long-term regression of a desmoid tumor with combined endocrine therapy using goserelin acetate plus tamoxifen. Tumor progression after 17 months was again stopped by a combination of interferon-gamma and goserelin acetate.
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