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Probes for optical imaging: new developments

2011; Elsevier BV; Volume: 8; Issue: 2-4 Linguagem: Inglês

10.1016/j.ddtec.2011.11.003

1740-6749

Kai Licha, Ute Resch‐Genger,

Analytical Chemistry and Sensors

Recent developments of fluorescent probes beyond approved indocyanine green (ICG) – itself increasingly spreading into new imaging applications like lymphatic mapping, arthritis imaging and tumor surgery – exploit various photophysical and biochemical mechanisms to monitor molecular events with higher specificity and accuracy. Emphasizing nanoparticulate formulations, targeted conjugates, activatable probes, probes with a sensor function and multimodality probes, this review discusses advantages and limitations of each type of probe, thereby critically assessing the desired translation into the clinic.