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BIBTEX RIS

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

2008; Nature Portfolio; Volume: 40; Issue: 12 Linguagem: Inglês

10.1038/ng.273

ISSN

1546-1718

Autores

Yufei Wang, Peter Broderick, Emily L. Webb, Xifeng Wu, Jayaram Vijayakrishnan, Athena Matakidou, Mobshra Qureshi, Qiong Dong, Xiangjun Gu, Wei Vivien Chen, Margaret R. Spitz, Timothy Eisen, Christopher I. Amos, Richard S. Houlston,

Tópico(s)

Genetic Associations and Epidemiology

Resumo

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).

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