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MICROTUBULE IONIC CONDUCTION AND ITS IMPLICATIONS FOR HIGHER COGNITIVE FUNCTIONS

2010; Imperial College Press; Volume: 09; Issue: 02 Linguagem: Inglês

10.1142/s0219635210002421

1757-448X

Travis J. A. Craddock, Jack A. Tuszyński, Avner Priel, Holly Freedman,

Plant and Biological Electrophysiology Studies

Journal of Integrative NeuroscienceVol. 09, No. 02, pp. 103-122 (2010) Research ReportsNo AccessMICROTUBULE IONIC CONDUCTION AND ITS IMPLICATIONS FOR HIGHER COGNITIVE FUNCTIONSTRAVIS J. A. CRADDOCK, JACK A. TUSZYNSKI, AVNER PRIEL, and HOLLY FREEDMANTRAVIS J. A. CRADDOCKDepartment of Physics, University of Alberta, Edmonton, Alberta T6G 2G7, CanadaCorresponding author., JACK A. TUSZYNSKIDepartment of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, CanadaDepartment of Physics, University of Alberta, Edmonton, Alberta T6G 2G7, Canada, AVNER PRIELIsrael Institute for Advanced Research, Rehovot, IsraelDepartment of Physics, University of Alberta, Edmonton, Alberta T6G 2G7, Canada, and HOLLY FREEDMANCCMAR, FCT, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugalhttps://doi.org/10.1142/S0219635210002421Cited by:31 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThe neuronal cytoskeleton has been hypothesized to play a role in higher cognitive functions including learning, memory and consciousness. Experimental evidence suggests that both microtubules and actin filaments act as biological electrical wires that can transmit and amplify electric signals via the flow of condensed ion clouds. The potential transmission of electrical signals via the cytoskeleton is of extreme importance to the electrical activity of neurons in general. In this regard, the unique structure, geometry and electrostatics of microtubules are discussed with the expected impact on their specific functions within the neuron. Electric circuit models of ionic flow along microtubules are discussed in the context of experimental data, and the specific importance of both the tubulin C-terminal tail regions, and the nano-pore openings lining the microtubule wall is elucidated. Overall, these recent results suggest that ions, condensed around the surface of the major filaments of the cytoskeleton, flow along and through microtubules in the presence of potential differences, thus acting as transmission lines propagating intracellular signals in a given cell. 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