The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
2014; Nature Portfolio; Volume: 16; Issue: 8 Linguagem: Inglês
10.1038/ncb3015
ISSN1476-4679
AutoresSandra S. McAllister, Robert A. Weinberg,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoRecent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
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