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Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

2011; Wiley; Volume: 32; Issue: 6 Linguagem: Inglês

10.1002/humu.21477

1098-1004

Xiaomu Wei, Ángela Moncada-Pazos, Santiago Cal, Clara Soria‐Valles, Jared J. Gartner, Udo Rudloff, Jimmy Lin, Steven A. Rosenberg, Carlos López-Otı́n, Yardena Samuels,

Peptidase Inhibition and Analysis

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression. © 2011 Wiley-Liss, Inc.