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Plasma amino acid concentrations in normal adults ingesting aspartame and monosodium l-glutamate as part of a soup/beverage meal

1987; Elsevier BV; Volume: 36; Issue: 11 Linguagem: Inglês

10.1016/0026-0495(87)90028-x

1532-8600

Lewis D. Stegink, L. J. Filer, George L. Baker,

Sleep and Wakefulness Research

We tested the hypothesis that ingestion of monosodium l-glutamate with aspartame produces a marked increase in plasma glutamate and aspartate concentrations. Twelve normal adults (6 males, 6 females) ingested three different soup/beverage meals in a balanced Latin square design. One meal (A) provided no aspartame (APM) or monosodium l-glutamate (MSG); a second (B) provided 50 mg MSG/kg body weight; while the third (C) provided 50 mg MSG and 34 mg APM per kg body weight. Plasma glutamate (Glu) concentrations were not significantly affected by meal A but increased significantly after meals B and C (no significant difference between B and C). Plasma aspartate (Asp) concentrations were not significantly affected by meal A but increased significantly after meals B and C (values significantly higher after meal C than meal B). Plasma Glu + Asp concentrations were not significantly affected by meal A but increased significantly from a mean (±SD) baseline value of 5.64 ± 2.62 μmol/dL to high mean values of 23.1 ± 7.29 and 26.8 ± 9.74 μmol/dL after ingestion of meals B and C, respectively (no significant difference between meals B and C). Similarly, the area under the plasma Glu + Asp concentration-time curve did not differ significantly between meals B and C (624 ± 197 v 763 ± 277 μmol/dL × min, respectively). Peak plasma Glu + Asp concentrations for each subject (ignoring time) were also examined. The mean peak plasma Glu + Asp concentrations were 7.39 ± 2.77, 23.0 ± 6.61, and 27.3 ± 9.07 μmol/dL, respectively after meals A, B, and C.