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Two new phenolic compounds from Ficus rumphii and their antiproliferative activity

2014; Taylor & Francis; Volume: 28; Issue: 9 Linguagem: Inglês

10.1080/14786419.2014.891201

1478-6427

Mehtab Parveen, Ali Mohammed Malla, Mahboob Alam, Faheem Ahmad, Pedro Silva, Manuela Ramos Silva,

Phytochemicals and Antioxidant Activities

Two new compounds 2 and 4, along with two known compounds 1 and 3, were isolated for the first time from 95% ethanolic extract of the leaves of Ficus rumphii. Their structures were elucidated on the basis of chemical and physical evidences (elemental analysis, UV, IR, 1H NMR, 13C NMR and mass spectra) and comparison with the literature compounds. Structural authentication of compound 4 was further validated by single-crystal X-ray analysis and DFT calculations. The compounds 1–4 were screened for in vitro cytotoxicity against cancer and non-cancer cells and also tested for genotoxicity (comet assay). Compounds 2 and 4 displayed significant activity against HL-60 with IC50 values of 3.3 and 2.3 μM, respectively. The results revealed that compound 4 has better prospectus to act as cancer chemotherapeutic candidate which warrants further in vivo anticancer investigations.