The crystal structure of 1,2-dibenzoyl-1- tert -butylhydrazine, a nonsteroidal ecdysone agonist, and its effects on spruce budworm ( Choristoneura fumiferana )
1990; NRC Research Press; Volume: 68; Issue: 7 Linguagem: Inglês
10.1139/v90-181
ISSN1480-3291
AutoresTak Hang Chan, Awais Ali, James F. Britten, A. W. Thomas, George M. Strunz, A. Salonius,
Tópico(s)Insect Pheromone Research and Control
ResumoThe crystal structure of 1,2-dibenzoyl-1-tert-butylhydrazine (1), a nonsteroidal ecdysone agonist, has been established by direct methods and refined to a final R value of 0.038 for 2502 observed reflections. The crystals belong to the monoclinic system, a = 10.5114(7), b = 31.557(3), c = 11.1578(8) Å, β = 113.210(6)°, and the space group is P2 1 /n. The N—N bond in 1 was found to adopt a gauche conformation with a dihedral angle of −71.8° or −58.1°. The two amide functions adopt different planar conformations. The compound is found to have a potent effect on the development of spruce budworm (Choristoneurafumiferana) larvae, causing early apolysis and subsequent mortality at 0.2–10 ppm concentration in artificial diet. Keywords: ecdysone, agonist, spruce budworm, 1,2-dibenzoyl-1-tert-butylhydrazine.
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