Effect of Persea macrantha against acute inflammation and adjuvant-induced arthritis in rats
2009; Taylor & Francis; Volume: 47; Issue: 4 Linguagem: Inglês
10.1080/13880200902748437
ISSN1744-5116
AutoresYogesh A. Kulkarni, Sharad Gokhale, A. Veeranjaneyulu, Sanjay J. Surana, Anilkumar U. Tatiya,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoPersea macrantha (Nees) Kosterm (Lauraceae) is a traditional medicinal plant being used in the treatment of asthma and rheumatism. The present study evaluated the anti-inflammatory and anti-arthritic properties of different extracts of stem bark of Persea macrantha in rats. Anti-inflammatory activity was determined in albino rats in a model of acute plantar inflammation induced by carrageenan, while the serial extracts were tested for anti-arthritic activity in adjuvant-induced arthritis in rats. The petroleum ether extract (PE) and aqueous extract (AE) caused a significant inhibition (43.90% and 39.02%, respectively) of the carrageenan-induced paw edema at a dose of 200 mg/kg, when compared with control and reference drug, diclofenac. PE (200 mg/kg) significantly decreased primary lesions (30.95%), secondary lesions (37.14%) and total radiological score (6.33 ± 0.42) in adjuvant induced arthritis. The findings of this experimental animal study indicate anti-inflammatory and anti-arthritic properties of Persea macrantha and thus provide pharmacological support to the traditional use of Persea macrantha in the treatment and management of painful, arthritic inflammatory conditions.
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