Neurotransmitter receptor sites in human hippocampus: a quantitative autoradiographic study
1982; Elsevier BV; Volume: 247; Issue: 2 Linguagem: Inglês
10.1016/0006-8993(82)91264-1
ISSN1872-6240
AutoresAnat Biegon, Thomas C. Rainbow, J. John Mann, Bruce S. McEwen,
Tópico(s)Memory and Neural Mechanisms
ResumoThe distribution of serotonin1, cholinergic-muscarinic, α-adrenergic and opiate-type receptors was studied in the human hippocampus by quantitative autoradiography. Each receptor type exhibited a unique distribution. Serotonin1 receptors were found to predominate in the subiculum, whereas α1-adrenergic receptor are absent in that area and present at high levels in the dentate and the CA fields. High densities of muscarinic receptors appear in the subiculum and dentate gyrus. Opiate receptors are restricted to a medial aspect of the subiculum, with lower levels in the dentate and CA fields. The high anatomical resolution and quantitative character of the data may make it useful in the investigation of hippocampal pathology in humans.
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