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Exposure Assessment and Risk Characterization for Perfluorooctanoate in Selected Consumer Articles

2005; American Chemical Society; Volume: 39; Issue: 11 Linguagem: Inglês

10.1021/es048353b

1520-5851

Stephen T. Washburn, Timothy S. Bingman, R. Scott Braithwaite, Robert C. Buck, L. William Buxton, Harvey J. Clewell, Lynne Haroun, Janet E. Kester, Robert W. Rickard, Annette M. Shipp,

Quantum Electrodynamics and Casimir Effect

An exposure assessment and risk characterization was conducted to better understand the potential human health significance of trace levels of perfluorooctanoate (PFO) detected in certain consumer articles. PFO is the anion of perfluorooctanoic acid (PFOA). Concentrations of PFO in the consumer articles were determined from extraction tests and product formulation information. Potential exposures during consumer use of the articles were quantified based on an assessment of behavior patterns and regulatory guidance. Health benchmarks were developed and then compared to the exposure estimates to yield margins of exposure (MOEs). A simple one-compartment model was also developed to estimate contributions of potential consumer exposures to PFO concentrations in serum. While there are considerable uncertainties in this assessment, it indicates that exposures to PFO during consumer use of the articles evaluated in this study are not expected to cause adverse human health effects in infants, children, adolescents, adult residents, or professionals nor result in quantifiable levels of PFO in human serum.