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New Lignans from the Leaves and Stems of Kadsura philippinensis

2013; Multidisciplinary Digital Publishing Institute; Volume: 18; Issue: 6 Linguagem: Inglês

10.3390/molecules18066573

1433-1373

Yu‐Chi Lin, Yuan‐Bin Cheng, Chia‐Ching Liaw, I‐Wen Lo, Yao‐Haur Kuo, Michael Y. Chiang, Chang‐Hung Chou, Ya‐Ching Shen,

Phytochemistry and Biological Activities

Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1-5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.