Primary Small Cell Carcinoma of the Larynx
1994; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês
10.1016/s0385-8146(12)80032-0
ISSN1879-1476
AutoresAkihiro Shiotani, Mitsuhiro Kawaura, Hiroyuki Fukuda, Yoichi Tanaka, Tsukasa Sako, Shunichi Sasaki, Ryohei Sakaguchi, Toshiyuki Kusuyama, Masahiro Kawaida, Jin Kanzaki,
Tópico(s)Chromatin Remodeling and Cancer
ResumoSmall cell carcinoma is a rare tumor of the larynx. We present such a case in a 78-year-old female. The histopathological diagnosis at the time of laryngomicroscopic biopsy was squamous cell carcinoma, upon which basis we initially chose surgical treatment. The surgical specimen, however, revealed small cell carcinoma. Despite the administration of radiotherapy and chemotherapy, the patient died 9 months after initial presentation. We believe that this case illustrates the need for a sufficiently large biopsy specimen in order to arrive at the correct histopathological diagnosis when small cell carcinoma of the larynx is present, and that immunohistochemistry and electron microscopy should be performed to aid the diagnosis. Small cell carcinoma is a rare tumor of the larynx. We present such a case in a 78-year-old female. The histopathological diagnosis at the time of laryngomicroscopic biopsy was squamous cell carcinoma, upon which basis we initially chose surgical treatment. The surgical specimen, however, revealed small cell carcinoma. Despite the administration of radiotherapy and chemotherapy, the patient died 9 months after initial presentation. We believe that this case illustrates the need for a sufficiently large biopsy specimen in order to arrive at the correct histopathological diagnosis when small cell carcinoma of the larynx is present, and that immunohistochemistry and electron microscopy should be performed to aid the diagnosis.
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