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Towards the Discovery of New Hypnotic Agents: Synthesis and Preliminary Pharmacological Evaluation of a Novel Class of Dibenzo[a,d]cycloheptene Derivatives

2010; Wiley; Volume: 5; Issue: 11 Linguagem: Inglês

10.1002/cmdc.201000280

1860-7187

Emiliano Castiglioni, Romano Di Fabio, Andrea Togninelli, Stephen Brough, Fiona Brown, Michele Dal Cin, Massimo Gianotti, Carla Marchioro, Giancarlo Merlo, Raffaella Spinosa, Mark Wigglesworth, Maurizio Botta,

Pharmacological Receptor Mechanisms and Effects

Sweet dreams are made of this! Spirotetracyclic derivatives designed from mirtazapine and mianserin were synthesized and key examples were evaluated in vitro. A potent dual 5HT2A and H1 receptor antagonist has been identified as an appealing lead to identify potential drug candidates for the treatment of sleep disorders. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.