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Open-tubular liquid chromatography—mass spectrometry with a capillary-inlet interface

1987; Elsevier BV; Volume: 385; Linguagem: Inglês

10.1016/s0021-9673(01)94616-3

1873-3778

W.M.A. Niessen, H. Poppe,

Mass Spectrometry Techniques and Applications

Abstract The capillary-inlet interface is a very simple and inexpensive interface for the coupling of open-tubular liquid chromatography (OTLC) and mass spectrometry (MS). It shows some attractive features from both the mass spectrometric and the chromatographic point of view. Due to the flow-rates applied with 5–10 μm I.D. open-tubular columns, it is possible to obtain on-line electron-impact spectra with the OTLC—MS system. However, the range of applicability of this interface appears to be limited to volatile compounds. Various aspects concerning the coupling of OTLC and MS are discussed: the experimental set-up, chromatographic performance, mode of ionization, range of applicability and detection limits.