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Pharmacokinetics of Ketoprofen in Patients with Chronic Renal Failure

1981; Taylor & Francis; Volume: 10; Issue: 3 Linguagem: Inglês

10.3109/03009748109095297

1502-7732

G Stafanger, Hans‐Walther Larsen, Henrik Post Hansen, K. Serensen,

Antibiotics Pharmacokinetics and Efficacy

The pharmacokinetics of ketoprofen were studied in 7 volunteers and in 5 patients suffering from varying degrees of renal insufficiency. All the subjects received a single oral dose (50 mg) of ketoprofen. Plasma concentrations were measured up to 24 hours after administration and urinary excretion for 2 days. Ketoprofen concentrations were determined by mass-fragmentography with a minimum level of detection of 0.02 mg/1. As expected, a reduction of the [51Cr]EDTA clearance was correlated with an increase in the elimination half-life of ketoprofen. The urinary excretion corresponded to results reported by other groups.